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Monday, May 4, 2020 | History

3 edition of Synergism and antagonism in chemotherapy found in the catalog.

Synergism and antagonism in chemotherapy

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  • 12 Currently reading

Published by Academic Press in San Diego .
Written in English

    Subjects:
  • Drug synergism.,
  • Drug antagonism.,
  • Chemotherapy, Combination.,
  • Drug Antagonism.,
  • Drug Synergism.,
  • Drug Therapy, Combination.

  • Edition Notes

    Includes bibliographical references and index.

    Statementedited by Ting-Chao Chou, Darryl C. Rideout.
    ContributionsChou, Ting-Chao., Rideout, Darryl C., 1956-
    Classifications
    LC ClassificationsRM302.3 .S96 1991
    The Physical Object
    Paginationxvi, 752 p. :
    Number of Pages752
    ID Numbers
    Open LibraryOL1849492M
    ISBN 100121740900
    LC Control Number90000898

      Book Notes | 1 January Antimicrobial Agents and Chemotherapy— Smaller groups of papers focus on antibiotic synergism, antagonism, and modes of action. Three major sections contain papers on new and synthetic antibiotics, including nebramycin, monensin, U,, LL-AB, oxolinic acid, and furazolium chloride, and new. time ism or antagonism was defined as either a 2-log 10 increase or decrease in CFU/mL with the combi-nation at 24 hours when compared to the most active single drug alone. Additivity was defined as less than 1-log 10 change in activity at 24 hours. Bacterial killing at 8 and 24 hours was measured by subtracting the bacterial. Microbiologists commonly use a two-dimensional, two-agent broth microdilution checkerboard to evaluate combinations of antimicrobial agents against microorganisms. A broth macrodilution limited series, agar dilution method, or disk diffusion method can also be used. Test methods are based on CLSI broth dilution susceptibility methods (1) for evaluating the inhibitory or bactericidal activity. Title:Evaluation of the Synergism Mechanism of Tamoxifen and Docetaxel by Nanoparticles VOLUME: 19 ISSUE: 16 Author(s):Zhihong Zhu, Hao Pan*, Yuenan Li and Weisan Pan* Affiliation:College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, , College of Pharmacy, Liaoning University, Shenyang , College of Pharmacy, Liaoning University, Shenyang , Author: Zhihong Zhu, Hao Pan, Yuenan Li, Weisan Pan.


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Synergism and antagonism in chemotherapy Download PDF EPUB FB2

Modified from “Quantitation of Synergism and Antagonism of Two or More Drugs by Computerized Analysis,” Chou TC, in Synergism and Antagonism in Chemotherapy (Chou TC. Synergism and Antagonism in Chemotherapy by Ting-Chao Chou (Author), Darryl C.

Rideout (Editor) ISBN ISBN Why is ISBN important. ISBN. This bar-code number lets you verify that you're getting exactly the right version or edition of a book. ISBN: OCLC Number: Description: xvi, pages: illustrations ; 24 cm: Contents: Part 1 Reviews and methods of quantitation: synergism, antagonism and potentiation in chemotherapy - an overview, t and ; the median effect principle and the combination index as tools for quantitation of synergism and antagonism, ; clinical studies of.

Synergism, Antagonism, and Potentiation in Chemotherapy: An Overview 3 DARRYL C. RIDEOUT AND TING-CHAO CHOU I. Drug Combinations in Chemotherapy 6 II. Mechanisms of Interaction 25 III. Condition-Related Aspects of Synergism, ; Antagonism, and Potentiation 51 References 53 CHAPTER 2 The Median-Effect Principle and the Combination IndexCited by:   In future, the Journal of Antimicrobial Chemotherapy will therefore insist that authors submitting papers containing FICI data restrict themselves to interpretations of ‘synergy’ (FICI ≤ ), ‘antagonism’ (FICI > ) and ‘no interaction’ (FICI > –).

This will encourage conservative interpretation of results and means Cited by: Enhance The Synergism And Antagonism In Chemotherapy Pp 4 60 San Diego California Academic Press Inc Chou Tc And Talalay P Antagonism In Chemotherapy Pdf Book Jan 26 Astrid Lindgren Ltd Modied Synergism and antagonism in chemotherapy book Quantitation Of Synergism And Antagonism Of Two.

synergy [sin´er-je] 1. correlated action or cooperation by two or more structures or drugs. in neurology, the faculty by which movements are properly grouped for the performance of acts requiring special adjustments.

adj., adj synerget´ic, syner´gic, synergis´tic. synergism (sin'ĕr-jizm), Coordinated or correlated action of two or more. Synergism manifests in a curve, or local part of a curve, lying above this line, and antagonism is below it.

The curves generated are schematic and intended solely for illustration; there are four kinds: pure synergism, pure antagonism, synergism turning into antagonism, and antagonism turning into synergism. Synonym (s): Synergism, Synergy.

An interaction between two or more drugs that causes the total effect of the drugs to be greater than the sum of the individual effects of each drug. A synergistic effect can be beneficial or harmful.

Related Term (s): Drug Antagonism. SPECK RS, JAWETZ E, GUNNISON JB. Studies on antibiotic synergism and antagonism; the interference of aureomycin or terramycin with the action of penicillin in infections in mice.

AMA Arch Intern Med. Aug; 88 (2)–Cited by: Abstract. This chapter describes and discusses the differentiation and quantitation of combined effects with respect to synergism or potentiation on the one hand, and antagonism on the other, in complex the combinations considered here, the Synergism and antagonism in chemotherapy book exhibit Author: Gerald Pöch.

In vitro and clinical studies established firmly this indication for antibiotic combination use, 35 Since that time, synergism as well as antagonism has been a subject of interest to microbiologists, biochemists, and molecular biologists, who developed in vitro studies with most of the marketed antimicrobials.

In in vivo studies involving Cited by: synergism or antagonism. Nash (24) emphasized that the results of this calculus method could be questionable.

Positive (or negative) interaction and synergism (or antagonism) may represent two dif- ferent phenomena. Despite an interaction, one cannot Synergism and antagonism in chemotherapy book whether the response to a mixture is above or below some ex- pected level.

2 An R Package for Assessing Drug Synergism/Antagonism experiments, where cancer cells are exposed to a drug for a speci ed length of time (typically 72 hours) and then cell viability is indirectly measured, usually via uorescence readings after addition of a suitable dye. Such cytotoxicity assays use multi-well incubation trays, where.

JAWETZ E. Antibiotic synergism and antagonism; review of experimental evidence. AMA Arch Intern Med. Sep; 90 (3)– JAWETZ E. Combined antibiotic therapy in serious infections caused by drug-resistant staphylococci ().

AMA Arch Intern Med. Feb; (2)–Cited by: 1. In the article by H. Veldstra on Synergism and Potentiation which appeared in Pharmacological Reviews, volume 8, number 3, Septemberthe left half of figure 1 on page was inadvertently omitted.

The complete figure 1 and its legend, reproduced below, should be substituted for the incomplete figure which appeared in the by: The synergism that results when heat and chemotherapy are used concurrently in the treatment of cancer is extensively documented.

– The exact molecular mechanisms at work when heat enhances the effect of chemotherapy or radiotherapy are unclear in all instances.

Possible mechanisms may include “direct cytotoxic effect of heat, and. a) Provide synergism resulting from the use of anticancer drugs with different mechanisms combination. b) Provide synergism resulting from the use of anticancer drugs with the same mechanisms combination.

c) Provide stimulation of immune system. d) Provide stimulation of cell proliferation. synergism: Interaction between two or more agents, entities, factors, or substances that produces an effect greater than the sum of their individual effects.

Also called synergetic effect or synergistic effect, it is opposite of antagonism. Ting-Chao Chou (born in Taiwan, Chinese name: 周廷潮) is a Chinese American theoretical biologist, pharmacologist, cancer researcher and inventor.

His scientific articles have been cited in 26, papers in over biomedical journals as of May 5, [1] He derived the median-effect equation (MEE) from the physico-chemical principle of the mass-action law, and introduced the.

Synergism through combination of chemotherapy and oxidative stress-induced autophagy in A lung cancer cells using redox-responsive nanohybrids: A new strategy for cancer therapy Author links open overlay panel Hsin-Yi Lu a b 1 Ya-Ju Chang b 1 Nien-Chu Fan b 1 Li-Sheng Wang b Nien-Chu Lai a Chia-Min Yang a Li-Chen Wu c Ja-an Annie Ho a b.

Permissiveness, Synergism and Antagonism. STUDY. Flashcards. Learn. Write. Spell. Test. PLAY. Match. Gravity. Created by. GENdj. Endocrine system. Terms in this set (3) Permissiveness. one hormone must be present for the full effect of another hormone.

The Lancet ORIGINAL ARTICLES SYNERGISM AND ANTAGONISM AS DISPLAYED BY CERTAIN ANTIBACTERIAL SUBSTANCES JosephW. Bigger M.D., Sc.D. Dubl., F.R.C.P., F.R.C.P.I. PROFESSOR OF BACTERIOLOGY, TRINITY COLLEGE, DUBLIN IT has already been shown (Bigger, ) that two antibacterial substances may display either synergism with or antagonism to one Cited by: Different types of interactions can occur at different target sites for the same combination of two chemicals.

For example, chlorinated insecticides and halogenated solvents (which are often used together in insecticide formulations) can produce liver toxicity with the interaction being additive.

The same combination of chemicals produces a different type of interaction on the central nervous. Synergism and antagonism. Eliopoulos GM(1). Author information: (1)Harvard Medical School, Massachusetts.

Among the reasons for use of antimicrobials in combination is the desire to achieve synergistic inhibitory or bactericidal activity. Several methods have been used to test for the presence of synergistic interactions, but virtually all are.

An R Package for Assessing Drug Synergism/Antagonism Synergistic and antagonistic drug interactions are important to consider when developing mixtures of anticancer or other types of drugs.

Boik, Newman, and Boik () proposed the MixLow method as an alternative to the Median-Effect method of Chou and Talalay () for estimating drug. MICROBIAL INTERRELATIONSHIP: BACTERIAL SYNERGISM AND ANTAGONISM What is Synergism. Synergism occurs when two organisms grow better together than apart (mutualism) or when the by-products of one organism enhances the survival.

It may allow secondary or superinfections to develop, by killing normal flora reduces microbial antagonism Compare & contrast the actions of polyenes, azoles, allyamines & polymyxin.

POLYENES - Nysatin & amphortericin B - Disrupts cytoplasmic membrane of cell & causing lysis to cell. Synonym (s): Drug Opposition. An interaction between two or more drugs that have opposite effects on the body.

Drug antagonism may block or reduce the effectiveness of one or more of the drugs. Related Term (s): Drug Synergism. Synergism definition: the working together of two or more drugs, muscles, etc, to produce an effect greater | Meaning, pronunciation, translations and examples.

Is opposite to antagonism, i.e., two or more agents create stronger effect than the predicted sum of their individual effects. Xenobiotics. History. The words synergy and synergetic have been used in the field of physiology since at least the middle of the 19th century.

SYN'ERGY, Synergi'a, Synenergi'a, (F.) Synergie; from συν, 'with', and εργον, 'work'.A correlation or concourse of action between different organs in health; and, according to some, in disease.

—Dunglison, Robley Medical Lexicon Blanchard and Lea, Moreover, it is not at all clear how these effects should precisely be described. Starting from definitions of interactions between different environmental influences introduced by Ott [7] and one of the present authors [8], new concepts of synergism (and antagonism and superposition) in a deterministic context will be presented.

Combined effects of Drugs, Pharmacology 1. COMBINED EFFECTS OF DRUGS By: Dr. Dhruva Kumar Sharma Department of Pharmacology Moderator: Dr. Supratim Datta Associate Professor Department of Pharmacology SMIMS 2.

Protocol: Summation Additive effects. Here are a large number of synergism examples, since many involve the same drug or class of drug I gave you larger number. Keep in mind that although we typically know what the effects of two or more drugs have the mechanism for the synergistic effect is not well understood (it may not be understood at all).

Two drugs that produce overtly similar effects will sometimes produce exaggerated or diminished effects when used concurrently. A quantitative assessment is necessary to distinguish these cases from simply additive action.

This distinction is based on the classic pharmacologic definition of additivity that, briefly stated, means that each constituent contributes to the effect in accord with Cited by: That paper really helped a lot on explaining the importance of cataloging both synergism and antagonism combinations in order to fully understand the network/mechanisms in cancer biology.

All. Blog. 13 May Stay connected to your students with Prezi Video, now in Microsoft Teams; 12 May Remote work tips, tools, and advice: Interview with Mandy Fransz.

Permissiveness is the situation in which a hormone cannot exert its full effects without the presence of another hormone. Synergism occurs when two or more hormones produce the same effects in a target cell and their results are amplified.

Antagonism occurs when a hormone opposes or reverses the effect of another hormone. Key Terms. 29 Combination Chemotherapy in Cancer: Principles, Evaluation and Drug Delivery Strategies Ana Catarina Pinto 1, João Nuno Moreira 2,3 and Sérgio Simões 1,2,3 1Bluepharma, Indústria Farmacêutica S.

A., S. Martinho do Bispo, Coimbra 2Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra. Synergism, in general, may be defined as two or more agents working together to produce a result not obtainable by any of the agents independently.

Antagonism is the opposite of Synergism, i.e two or more agents working in opposite actions.The Chemotherapy Source Book, Fourth Edition pulls together all the current information on the chemotherapeutic management of cancer patients, including choice of chemotherapeutic agents, use of combinations, and toxicity of individual drugs.

Organized by disease site, the book brings together pharmacologic and patient management information in one source that clinicians can consult for any. Pharmacodynamics of antibiotics 1. Pharmacodynamics of antibiotics Capt. Htet Wai Moe Resident Pharmacology 2.

• The time course of drug concentration is closely related to the antibiotic effect at the site of infection and to any toxic effects • Pharmacodynamic factors include pathogen susceptibility testing, drug bactericidal versus bacteriostatic activity, drug synergism, antagonism and.